Twins DNA Testing | Panorama Trisomy Testing | Natera

PRODUCT SPOTLIGHT

Panorama demonstrates utility of measuring individual fetal fractions in twin pregnancies

PRODUCT SPOTLIGHT

Panorama test demonstrates unique ability to determine zygosity in twin pregnancies


Panorama Twins DNA Testing

For twin pregnancies, only the Panorama twin DNA test can provide:


  • Zygosity information (identical or non-identical twins)
  • Individual fetal fractions for dizygotic (non-identical) twins
  • Fetal sex for each twin
  • Monosomy X risk for monozygotic (identical) twins

Other conditions screened:

  • Trisomy 21
  • Trisomy 18
  • Trisomy 13
  • Sex chromosome trisomies (reported when seen)*
  • 22Q11.2 deletion syndrome (optional)*

*Identical twins only

Download: Panorama Twins

 


The only prenatal blood test that can tell you whether your twins are identical or fraternal

Looking for a blood test to determine the gender of twins? Panorama is the only non-invasive prenatal test, or NIPT, that can distinguish between each twin’s DNA. This NIPT for a twin pregnancy can tell you:

  • Whether your twins are identical (from the same egg) or fraternal (from separate eggs)
  • The sex of each twin

In addition to providing NIPT for twins’ gender, Panorama includes trisomy testing and can be used as an NIPT for vanishing twin syndrome.


Two girls

 

One girl, one boy

 

Two boys

 


Panorama is the only prenatal blood test that can tell you whether your twins are identical or fraternal, and helps identify risk for more conditions than any other NIPT for twins


Panorama may help clinicians triage twin pregnancies effectively2-7

Panorama identified monozygotic twins with >99% sensitivity and specificity in a validation study.

While chorionicity can be reliably detected early in pregnancy, studies have shown that up to 19% of monochorionic pregnancies are incorrectly classified as dichorionic. Panorama allows clinicians to align their ultrasound findings with an early and accurate zygosity determination.

  • Identifying a monozygotic twin pregnancy with Panorama can prompt earlier, targeted ultrasound assessments for chorionicity and associated complications.
  • Knowing that a twin pregnancy is dizygotic reduces healthcare providers’ and patients’ concerns about twin-to-twin transfusion syndrome (TTTS).

Pregnancy management of twins is highly influenced by chorionicity; as such, Panorama’s zygosity determination can help healthcare providers determine an appropriate management plan.

Norwitz et al. J Clin Med. 2019 Jun; 8:937; doi:10.3390/jcm8070937. Blumenfeld et al. J Ultrasound in Med. 2014 Dec;33(12):2187-92.

Society for Maternal-Fetal Medicine, Clinical guideline: Twin-twin transfusion syndrome, Jan 2013.

American College of Obstetricians and Gynecologists and Society for Maternal-Fetal Medicine, practice bulletin #169, Oct 2016.

Oldenburg et al. Ultrasound Obstet Gynecol. 2012 Jan;39(1); 39: 69–74.

Chasen, Chervenak (2017). Twin pregnancy: Prenatal issues. In T. Post (Ed.), UpToDate. Waltham, Mass.: UpToDate. Retrieved from www.uptodate.com

Cunningham et al. Williams Obstetrics. 24th edition. New York: McGraw-Hill Education, 2014.