Prospera^™ Lung

Built for Confident Decisions

A noninvasive donor-derived cell-free DNA (dd-cfDNA) blood test for lung transplant rejection monitoring. Early insight into acute rejection risk may change everything.

Prospera™ Lung Transplant Assessment – the next generation

A single blood test to assess all transplant rejection types
The blood sample contains a mixture of donor DNA (shed from the donor organ) and patient DNA
Prospera™ differentiates between donor DNA and patient DNA using differences in single-nucleotide polymorphisms
Prospera™ reports the percentage of dd-cfDNA in the patient’s blood, a predictor of acute rejection

Experts in cell-free DNA

Optimized for transplant

Developed by Natera, a leader in cfDNA with a trusted legacy in fetal monitoring, oncology and organ health
Demonstrated in over 10 million tests¹
Utilizes over 13,000 pan-ethnic SNPs and advanced bioinformatics²
Optimized to be a precise cfDNA tool for early, clinically meaningful rejection assessment.³

Precision optimized for enhanced performance

Reduce the number of surveillance biopsies by monitoring with Prospera™ Lung

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New Publication! Single Lung Allograft Monitoring study (SLAM)⁴

SLAM is the largest study of commercial dd-cfDNA tests in single lung transplant (SLT)
The SLAM study is a multi-center, retrospective analysis from 6 academic lung transplant centers in the US.
The aim of the SLAM study is to demonstrate Prospera™ Lung performance in assessing transplant rejection in the single lung transplant (SLT) population.

SLAM study establishes Prospera™ Lung as an accurate, noninvasive transplant assessment for Single Lung Transplantation

Learn more about SLAM

Patients First, Partners Always

Natera’s suite of solutions allows for streamlined process integration for your center

Total EMRSync

A complete, secure bi-directional data and workflow interface with Epic and Cerner systems

Allows for easy ordering and delivery of results

ProsperaLink Program

A concierge team of clinical experts including a medical science liaison, nurse coordinator, & patient coordinator to help patients stay updated on blood draws, compliance plans and results.

Financial Support Program

Natera welcomes all insurances, and our goal is to make the process easy and transparent for patients
In the rare event your patient has financial responsibility, Natera offers flexible financial assistance programs and will work closely with your patient to ensure there is no hardship on them or their family.

Find out more about Prospera™ for lung transplant recipients

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References

¹Natera Inc. Natera validation data: manuscript submitted. Data on file.

²Sigdel TK, Archila FA, Constantin T, et al. Optimizing detection of kidney transplant injury by assessment of donor-derived cell-free DNA via massively multiplex PCR. J Clin Med. 2018 (per published article);8(1):19 doi:10.3390/jcm8010019

³Rosenheck JP, Ross DJ, Botros, M, et al. Clinical Validation of a Plasma Donor-derived Cell-free DNA Assay to Detect Allograft Rejection and Injury in Lung Transplant. Transplantation Direct. 2022;8(4) doi:10.1097/txd.0000000000001317

⁴Arunachalam A, Anjum F, Rosenheck JP, et al. Donor-derived Cell-free DNA is a Valuable Monitoring Tool after Single Lung Transplantation: Multi-center Analysis. JHLT Open. 2024. doi:https://doi.org/10.1016/j.jhlto.2024.100155

Prospera™ Lung