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Prospera

For kidney transplant assessment

 

Covered by Medicare, Prospera is a transplant rejection assessment test that uses a simple blood draw to evaluate the risk of rejection of a transplanted kidney.

Through the use of advanced cell-free DNA technology, Prospera increases a provider’s ability to identify otherwise undetected rejection that might lead to kidney loss. Catching transplant rejection as soon as possible can help providers develop a treatment plan to best protect the donated kidney.

Setting a new standard through research

Best-in-class care depends on best-in-class assessment

Prospera is the most advanced cfDNA solution for assessing transplant rejection — reinforced by ongoing research efforts.
Sigdel et al Clinical Validation: Published in 2019
  • Conducted with the University of California, San Francisco
  • Largest biopsy-matched study conducted in renal transplantation assessing the use of cell-free DNA
  • The first to publish performance of cell-free DNA testing in subclinical, surveillance setting

View: Sigdel et al paper

ProActive Registry Study: Now Enrolling
  • Largest clinical utility study evaluating cell-free DNA; includes more than 3,000 kidney transplants studied for three years
  • Long-term assessment of high-risk recipients for up to 5 years post-transplantation
  • Personalized transplant management protocols using cell-free DNA data

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Read about ProActive Recruitment Milestone
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Research with the Molecular Microscope Diagnostic System (MMDX): Now Enrolling
  • Global, prospective multicenter study under the leadership of Dr. Philip Halloran
  • 300 patients to be comprehensively evaluated with clinical information, cell-free DNA measures, biopsies, molecular microscope, evaluations, and donor-specific antibodies (DSA)
  • Integrated data analysis to better inform non-invasive and interventional management in kidney transplantation

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PEDAL Study: Now Enrolling
  • 500 kidney transplant patients from 20 major US centers
  • Evaluation of how quantifying the absolute concentration of background cell-free DNA (cfDNA) may allow for a more precise and confident assessment of allograft rejection — especially in identifying patients at-risk of false-negative interpretations

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Natera’s Innovations in Transplant Oncology
  • CONCERT Study: To accelerate clearance for renal transplantation in molecular residual disease (MRD)-negative patients with a history of colorectal cancer
  • PARC Study: To understand how malignancies and cancer therapy affect background cell-free DNA levels in renal allograft patients
  • SIGNAL Study: To observe Signatera in patients with liver cancer to determine molecular residual disease (MRD) rates before and after liver transplant

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MOTR Study: Now Enrolling
  • Study to determine utility of Prospera in multiple organ transplant patients
  • Evaluate 400 kidney-liver, kidney-pancreas and kidney-heart patients

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