How does it work?
From a simple blood draw, Prospera measures the amount of donor DNA from your transplanted heart in your blood. This helps your care team assess all types of rejection more precisely than using the available standard assessment tools alone.
What do the Prospera results mean to me?
The Prospera result represents the percent of cell-free DNA in your blood that originates from the donated heart to determine whether or not you may be experiencing active rejection. It may also indicate other types of heart injury you are experiencing.
Like your other regular monitoring tests, Prospera is recommended for periodic use over time as directed by your doctor.
A way to track your cell-free DNA over time
- Establishing a baseline tells you and your care team the “normal state” of your new heart. You can measure new results against this baseline.
- Following your levels in the future reveals your new heart’s health
If a Prospera result is above 0.15%
This may mean that active rejection is occurring. Terms used to describe the various types of active rejection include:
- Antibody-mediated rejection (AMR)
- Acute cellular rejection (ACR)
- Mixed rejection
To confirm a rejection and the type of rejection, you should consult with your doctor.
If a Prospera result is in the normal range
This may mean that your heart is stable.
Patients first, partners always
Sign up to find out if you’re eligible for Prospera
1Natera Inc. Natera validation data: manuscript submitted. Data on file.
2Sigdel TK, Archila FA, Constantin T, et al. Optimizing detection of kidney transplant injury by assessment of donor-derived cell-free DNA via massively multiplex PCR. J Clin Med. 2019;8(1):19.