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Horizon

Comprehensive, actionable carrier screening

Horizon carrier screening helps couples determine the risk of passing on serious genetic conditions to their child. It can be performed either preconception (ideally) or during pregnancy.

Carriers are common, and family history is not a predictor

Family history - Mom and daughter

Family history: not a predictor

88% of carriers of cystic fibrosis (CF), spinal muscular atrophy (SMA), and fragile X syndrome have no known family history1

Combined Incidence

Carrier frequency

1 in 9 people are carriers when screened with the Horizon 14 standard panel2

Combined Incidence

Combined incidence

1 in 634 babies born are affected by one of the conditions in the Horizon 14 standard panel2

The American College of Obstetricians and Gynecologists (ACOG) says…

quote_ACOG

Carrier screening is no longer a “nice-to-have”; it’s now best practice — regardless of ethnicity and screening strategy. ACOG recommends carrier screening for all patients either preconception or during pregnancy.3

The American College of Obstetricians and Gynecologists (ACOG)

Carrier screening facilitates informed decision-making and early preparation

s3_preconception

Preconception

  • Get genetic counseling
  • Pursue alternative reproductive options
s3_pregnancy

Pregnancy

  • Undergo diagnostic testing
  • Assemble an appropriate care team and specialist facility for delivery
  • Plan financially and prepare emotionally
s3_post delivery

Post-Delivery

  • Access early interventions including FDA-approved treatment and clinical trials
Renasight Genetic test for kidney disease

Leading-edge technology meets support for your patients and practice

Horizon carrier screening leverages next-generation sequencing technology to give your patients comprehensive insights on their risk of passing on serious genetic conditions. Horizon uniquely combines actionable results with support resources tailored for your patients and practice.

High detection rates — advanced technology detects more carriers

CF

Cystic fibrosis

Traditional genotyping tests can miss up to 44% of carriers detected by Horizon.2

ACOG says….“A number of expanded mutation panels…can be considered to enhance sensitivity for carrier detection, especially in non-Caucasian ethnic groups.”4

SMA

Spinal muscular atrophy

Traditional screening misses ~60% of patients Horizon identifies as at risk.2

ACOG says…“[A subset] of the general population…will not be identified as being a carrier…”4

Hemo

Hemoglobinopathies

CBC (complete blood count) and electrophoresis testing alone could miss 90% of alpha- and 6% of beta-hemoglobinopathy carriers detected by Horizon.2

ACOG says…“A combination of laboratory tests may be required to provide the information necessary to counsel couples…”4

Comprehensive support — tools and services meeting provider and patient needs

Order

Ordering

Horizon / Panorama Combo Kit requires only one blood draw, requisition form, and kit.

NEVA

Results

The Patient Call-Out Program (PCOP) delivers results and provides interactive genetic education via NEVA (Natera’s Educational Virtual Assistant), available 24/7.

Patner-testing

Partner Testing

Partner Auto-Enroll streamlines your workflow for testing partners of patients with positive Horizon results.

References

1Archibald, A., Smith, M., Burgess, T. et al. Genet Med 20, 513–523 (2018). https://doi.org/10.1038/gim.2017.134

2Westemeyer, M., Saucier, J., Wallace, J. et al. Genet Med (2020). https://doi.org/10.1038/s41436-020-0807-43.

3American College of Obstetricians and Gynecologists, Committee Opinion #690, March 2017.

4American College of Obstetricians and Gynecologists, Committee Opinion #691, March 2017.