Anora™ Clinician Information
Most comprehensive miscarriage test
Anora helps determine why a miscarriage occurred. Testing is performed on the tissue from the pregnancy loss.
Anora tests for chromosomal abnormalities and results are typically returned to your doctor within one week of sample receipt.
- Miscarriage test overview
- Sample Requirements & Shipping
- Results & Reporting
- Cost & Billing
Who should have miscarriage testing?
Miscarriage chromosome testing can be helpful if you:
- Would like to know if a miscarriage was caused by a chromosomal abnormality
- Have had more than one miscarriage (although your doctor can order Anora with the first loss)
- Have had a child or previous pregnancy with a chromosomal abnormality
The choice to have chromosome testing after a miscarriage is very personal. Although not all doctors will recommend chromosome testing for a pregnancy loss, it can be helpful for couples who have a miscarriage and want to know the cause.
What are the benefits of Anora?
Many couples struggle when experiencing a miscarriage; they wonder if they somehow caused the miscarriage to happen. Knowing that a miscarriage was caused by a random chromosomal abnormality may help you and your partner begin to heal from the loss of a pregnancy. You may wonder what the chances are of another miscarriage. Chances are low that a random chromosomal abnormality will recur. Anora miscarriage testing may give you answers to these, and other questions. If a random type of chromosomal abnormality is found, it may mean that other costly medical tests can be avoided.
Anora uses an advanced method of chromosome testing called Single Nucleotide Polymorphism (SNP) microarray and can detect more types of chromosome problems than other miscarriage testing methods.
When should I do Anora miscarriage testing?
Chromosome testing is usually done at the time that the miscarriage occurs. Tissue from the pregnancy (also called the products of conception) can be collected at the time of a D&C procedure or can be collected at home after spontaneous loss of a pregnancy. Testing may be possible on prior miscarriages if the tissue has been saved in paraffin. This type of testing may be helpful to patients who have had more than one pregnancy loss. Check with your doctor to see if a sample from a prior miscarriage has been saved.
What if I have miscarried before?
Miscarriage, although very difficult, is common. It is estimated that about 1 out of every 4 pregnancies ends in a miscarriage. Random chromosomal abnormalities are found in about half of all miscarriages. The chance of having a second miscarriage is typically not increased after one loss. If this is your second loss, you may be at higher risk to miscarry in the future. You may want to discuss further testing, including Anora, with your doctor to help determine if chromosomal abnormalities could be the cause for pregnancy loss.
What if I have a family history of genetic disease?
Most genetic diseases that run in a family are caused by changes within individual genes and not missing or extra chromosome material. Anora is not able to test for specific single gene disorders. You should discuss your family history with your doctor or a local genetic counselor to find out if other types of genetic testing are available to better understand your family history. One exception to this is chromosomal rearrangements, which can sometimes run in a family. It is estimated that about 1 in 500 people have the correct amount of genetic information, but it is arranged in a different way (called a balanced translocation or inversion). A carrier of a balanced rearrangement is healthy, but may be at increased risk for miscarriage or children with chromosomal abnormalities. Anora can provide helpful information that indicates a parent may be a balanced translocation or inversion carrier.
How do I request Anora from my doctor?
Let your doctor know that you have heard of a test called “Anora” that can look to see if your miscarriage was due to a chromosomal abnormality in the fetus. If they are not familiar with the test and would like to learn more, have them contact Natera to order a kit at 844-778-4700.
What type of sample do I submit?
Your doctor will submit the sample unless you are collecting the sample at home. For instructions for at-home collection, please download our Anora instructions document. We suggest that a sample of your blood (tube is provided in the Anora kit) be sent along with the tissue for the most comprehensive results.
How long do results take to get back to me?
Results are typically returned to your doctor within one week of sample receipt.
How will I know my results are available?
Your doctor will contact you to let you know your results.
How are results reported?
You can review a sample report to see how results are reported.
My test results found a chromosomal abnormality, what do I do next?
If a chromosomal abnormality is found, further testing may or may not be indicated. Your doctor will know the next best steps for you.
Most chromosomal abnormalities found through miscarriage tests like Anora are NOT inherited; they are the result of random chromosome errors that occur around the time a baby is conceived. These errors do happen more commonly as mothers get older. The specific type of abnormality found through Anora can assist your healthcare provider in determining whether you or your partner might carry a balanced translocation. Your healthcare provider will review the results and discuss whether to pursue a blood test for you or your partner to rule out a balanced rearrangement. Carriers of balanced translocations may be at higher risk to have a miscarriage or to have a child with too much or too little genetic information.
Who can I talk to about my Anora test results?
In addition to speaking to your doctor, we encourage you to speak to one of Natera’s board-certified genetic counselors for a complimentary information session before or after your test.
Book a complimentary information session with a genetic counselor.
What is the cost of Anora?
The cost of Anora is based on your insurance coverage. To understand your financial responsibility, please call Natera at 877-869-3052. You may be eligible for a payment plan and/or assistance for financial hardship*.
*Not everyone may qualify. Void where prohibited.
Does my insurance cover Anora?
Insurance coverage for Anora is contingent on your health insurance plan and coverage benefits. Please call Natera at 877-869-3052 in order to verify and check your insurance coverage options.
Click here to see in-network plans.
How do I pay my bill?
What is an EOB and what amount will it include?
An EOB is NOT a bill. EOB stands for Explanation of Benefits and describes how your insurance plan pays for your test and if there is any additional amount that you may be responsible for. The EOB typically precedes your bill. If you have any questions about your EOB, please call a Natera billing specialist at 877-869-3052.
- Ordering & Logistics
- Sample Requirements & Shipping
- Genetic Counseling
- Results & Reporting
How do I begin offering Anora in my practice?
You can contact Natera by calling 844-778-4700 or emailing email@example.com. You will be connected with our inside sales team who will set up an account for you.
What if I have other questions about Anora?
Click here to download the Anora clinical FAQ or contact Natera at 844-778-4700.
What type of sample should I send?
To run an Anora test, acceptable fresh tissue samples include chorionic villi, gestational sac, fetal skin/tissue, umbilical cord tissue, and cytogenetic tissue cell pellets. We recommend that a blood sample from the mother be sent with the tissue so that maternal cell contamination studies can be performed simultaneously. Paraffin POC testing is also available on either paraffin blocks or slides. Both parental samples (maternal and paternal blood or buccal samples) are required for paraffin testing. Please contact Natera at 844-778-4700 for more information on paraffin testing.
How long should samples be stored before shipping and how should they be sent?
Tissue and patient samples should be shipped to Natera as soon as possible. Tissue samples should be stored in the refrigerator overnight until the next possible shipping day and must be received within 30 days of sample collection. The blood tube (purple top), or alternatively a buccal (cheek) swab, can be stored in the refrigerator and must be received within 14 days of sample collection.
How can I contact a board-certified genetic counselor if I have questions about a patient result?
Board-certified genetic counselors are available to answer questions about Anora Monday through Friday, 6 AM to 5 PM Pacific Time, excluding holidays. Please call 844-778-4700 and ask to speak with the on-call genetic counselor. You may also email firstname.lastname@example.org with questions.