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Is your immunotherapy working?

Signatera can be used to help better manage your cancer treatment with a personalized approach that is as unique as you are. If you are being treated with immune checkpoint inhibitors (ICIs), a type of immunotherapy, you may have questions about whether the treatment is working for you. Medicare coverage now includes patients on immunotherapy, regardless of tumor type.
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Finding hope with Signatera™

When Steven was diagnosed with metastatic melanoma, he started to lose hope. After his oncologist ordered circulating tumor DNA (ctDNA) testing with Signatera, Steven found the peace of mind he needed to rediscover his purpose and joy. His tumor tissue was sequenced for its unique genomic variants, and now his oncologist uses serial blood draws to confirm that Steven remains cancer-free during immunotherapy. Watch Steven’s story now to learn more.

“When you are fighting the cancer, you want to stack the deck in your favor – you want all the details so you can make the call.”

Steven

Immunotherapy patient

Learn how Signatera works

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A one-time analysis of both blood and tissue determines your unique set of tumor mutations.

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The test is custom-built and personalized for you.

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Signatera detects the presence or absence of cancer each time it is ordered as part of your routine follow-up blood tests.

Learn how Signatera detects your cancer

Understand your Signatera test results

Your test results will either be positive or negative for the presence of ctDNA in your blood. Your doctor will receive the test report and discuss your results and answer questions.
IMPORTANT: Negative results may change over time. A negative Signatera result doesn’t guarantee that tumor DNA is not in your blood, or that it will never be detected in the future. This is why ongoing monitoring with the Signatera test over the course of your cancer care, as directed by your doctor, is recommended for early detection of residual disease
Negative result
A negative result indicates that tumor DNA was not detected in your blood. This means you are more likely to remain cancer-free if you were diagnosed with early stage cancer.
If you have metastatic cancer, a negative result may mean your treatment was able to decrease the number of cancer cells to undetectable levels, meaning the treatment has been effective.
Our Tests
Positive result
A positive result indicates that tumor DNA has been detected in your blood and means there is higher risk for your cancer returning if you were diagnosed with early-stage cancer. Your doctor may continue to monitor your ctDNA levels to assess your tumor’s response to treatment.
Our Tests
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Discover our BESPOKE study of Signatera-guided immuno-oncology (IO) therapy

Be a part of something truly groundbreaking. Join Natera’s BESPOKE IO study to make a difference for people who, like you, are managing cancer with immunotherapy or immuno-oncology (IO) treatment. The study will examine the use of Signatera and the impact it has on treatment decisions for clinical outcomes in cancer patients being treated through immunotherapy. The study will enroll more than 1,500 patients. Natera and its collaborators will collect data on clinical decisions, benefits, and outcomes from enrolled participants for up to two years.

Visit our Signatera BESPOKE IO page to learn more about joining the study.

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Check out FAQs to learn more about Signatera

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Submit your inquiries here.