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Understanding Hereditary Cancer Risks in Ovarian Cancer

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While most ovarian cancers are sporadic, up to 25% are linked to inherited genetic mutations. Knowing your family history—and your genes—can be a powerful tool in prevention and early detection.

  • Key Genetic Mutations:
    BRCA1 and BRCA2 mutations account for the majority of hereditary ovarian cancers. Others include Lynch syndrome (MLH1, MSH2, MSH6, PMS2), Li-Fraumeni syndrome (TP53), and PALB2.

  • Who Should Consider Genetic Testing?
    Women with a personal or family history of ovarian, breast, or colorectal cancer—especially those of Ashkenazi Jewish descent—should talk to their provider about testing.

  • Why It Matters:
     Genetic testing can inform risk-reduction strategies, such as increased surveillance or preventive surgery. It also helps guide treatment decisions and family planning.

Understanding hereditary risk isn’t just about genetics—it’s about empowerment. This Ovarian Cancer Awareness Month, let’s encourage conversations that lead to informed choices and proactive care. Talk to your doctor about whether Signatera™ MRD testing or Empower™ hereditary cancer testing could help you stay ahead and make more informed treatment decisions.