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Organ Health Publications

Renasight | Prospera Kidney | Prospera Lung | Prospera Heart

Renasight

  1. Stein Q, Herman K, Deyo J, et al. Dual diagnosis of autosomal dominant polycystic kidney disease and sickle cell disease in a teenage male. Pediatr Nephrol. (2023). 38(9):3189-3192. doi: 10.1007/s00467-023-05873-6
  2. Stein Q, Westemeyer M, Darwish T, et al. Genetic Counseling in Kidney Disease: A Perspective. Kidney Medicine (2023). 5(7):100668. doi: 10.1016/j.xkme.2023.100668.
  3. Shi V, Stein Q, Clark D, et al. Isolated benign persistent proteinuria with novel association of CUBN (cubilin) variants. 11(6):e7502. doi: 10.1002/ccr3.7502
  4. Dahl N, Bloom MS, Chebib FT, et al. The Clinical Utility of Genetic Testing in the Diagnosis and Management of Adults With Chronic Kidney Disease. J Am Soc Nephrol ():10.1681/ASN.0000000000000249.
  5. Bleyer AJ, Westemeyer M, Xie J, et al. Genetic Etiologies for Chronic Kidney Disease Revealed through Next-Generation Renal Gene Panel. Am J Nephrol. 2022. 53(4):297-306.
  6. Singh G, Gohh R, Clark D, et al. Vignette-Based Reflections to Inform Genetic Testing Policies in Living Kidney Donors. Genes. 2022;13(4).
  7. Cocorpus J, Hager MM, Benchimol C, et al. COL4A4 variant recently identified: lessons learned in variant interpretation-a case report. BMC Nephrol. 2022;23(1):253.
  8. Tantisattamo E, Reddy UG, Ichii H, et al. Is It Time to Utilize Genetic Testing for Living Kidney Donor Evaluation? Nephron 2021. doi: 10.1159/000520150
  9. Mrug M, Bloom MS, Seto C, et al. Genetic Testing for Chronic Kidney Diseases: Clinical Utility and Barriers Perceived by Nephrologists. Kidney Medicine

    (2021) doi: https://doi.org/10.1016/j.xkme.2021.08.006.

  10. Chaperon JL, Wemmer NM, McKanna TA, et al. Preimplantation Genetic Testing for Kidney Disease-Related Genes: A Laboratory’s Experience. Am J Nephrol 2021. doi: 10.1159/000518253

Prospera Kidney

  1. Bromberg, et al. Elevation of Donor-derived Cell-free DNA Before Biopsy-proven Rejection in Kidney Transplant. Transplantation. 2024
  2. Halloran, et al. Distinct Molecular Processes Mediate Donor-derived Cell-free DNA Release From Kidney Transplants in Different Disease States. Transplantation. 2023
  3. Halloran PF, Reeve J, Madill-Thomsen KS, et al. The Trifecta study: comparing plasma donor-derived cell-free DNA levels with the molecular phenotype of kidney transplant biopsies. J Am Soc Nephrol. 2022. 33(2):387-400.
  4. Ventura-Aguiar P, Ramirez-Bajo MJ, Rovira J, et al. Donor-derived Cell-free DNA Shows High Sensitivity for the Diagnosis of Pancreas Graft Rejection in Simultaneous Pancreas-kidney. Transplantation. 2022;106(8):1690-1697.
  5. Reusing Jr JO, Yoo J, Desai A, et al. Association between total cell free DNA and SARS-CoV-2 in Kidney Transplant Patients: A Preliminary Study. Transplantation Proceedings. 2022; 54(6):1446-1454.
  6. Halloran PF, Reeve J, Madill-Thomsen KS, et al. Combining Donor-derived Cell-free DNA Fraction and Quantity to Detect Kidney Transplant Rejection Using Molecular Diagnoses and Histology as Confirmation. Transplantation. 2022.
  7. Halloran PF, Reeve J, Madill-Thomsen KS, et al. Antibody-mediated Rejection Without Detectable Donor-specific Antibody Releases Donor-derived Cell-free DNA: Results From the Trifecta Study. Transplantation. 2022.
  8. Qazi Y, Patel A, Fajardo M, et al. Incorporation of Donor-derived Cell-free DNA Into Clinical Practice for Renal Allograft Management. Transplant Proc. 2021. 10:S0041-1345(21)00710-7. doi: 10.1016/j.transproceed.2021.09.027.
  9. Lum EL, Nieves-Borrero K, Homkrailas P, et al. Single center experience comparing two clinically available donor derived cell free DNA tests and review of literature. Transplantation Reports. 2021;6(3).
  10. Bunnapradist S, Homkrailas P, Ahmed E, et al. Using Both the Fraction and Quantity of Donor-Derived Cell-Free DNA to Detect Kidney Allograft Rejection. J Am Soc Nephrol 2021:32 (10) 2439-2441; DOI: 10.1681/ASN.2021050645
  11. Bunnapradist S, Datta N, Schaenman J, et al. Extremely High Cell-free DNA Levels Observed in Renal Allograft Patient With SARS-CoV-2 Infection. Transplantation Direct. 2021;7(5)
  12. Peabody J, Billings P, Valdenor C, et al. Randomized clinical trial of a novel donor derived cfDNA test to detect rejection in CPV-simulated renal transplant patients. Int Urol Nephrol. 2020; 52(8):1593-1601.
  13. Altug Y, Demko ZP, Ryan A. The Author's reply to the "Performance of Donor-derived Cell-free DNA Assays in Kidney Transplant Patients". Letter to the Editors - Transplantation. 2020;104(5):e135-137
  14. Peabody J, Billings P, Valdenor C, et al. Variation in assessing renal allograft rejection: a national assessment of nephrology practice. International Journal of Nephrology. Vol. 2019; Article ID 5303284, 6 pages.
  15. Altuğ Y, Liang N, Ram R, et al. Analytical Validation of a Single-Nucleotide Polymorphism-Based Donor-Derived Cell-Free DNA Assay for Detecting Rejection in Kidney Transplant Patients. Transplantation. 2019;103(12):2657-2665.
  16. Sigdel TK, Acosta Archila F, Constantin T, et al. Optimizing Detection of Kidney Transplant Injury by Assessment of Donor-Derived Cell-Free DNA via Massively Multiplex PCR. J Clin Med. 2019;8(1):19.

Prospera Lung

  1. Arunachalam, Ambalavanan et al. Donor-derived Cell-free DNA is a Valuable Monitoring Tool after Single Lung Transplantation: Multi-center Analysis JHLT Open, Volume 0, Issue 0, 100155
  2. Girgis R, Lawson C, Bhorade S, et al. Real-World Clinical Experience Implementing Donor-Derived-Cell Free DNA for Detection of Acute Lung Allograft Dysfunction after Lung Transplantation. Mar Pulmonology and Respiratory Medicine (2023) 6:3. DOI:10.1027/margy.2023.0156.
  3. Rosenheck JP, Ross DJ, Botros, M, et al. Clinical Validation of a Plasma Donor-derived Cell-free DNA Assay to Detect Allograft Rejection and Injury in Lung Transplant. Transplantation Direct. 2022;8(4).
  4. Rosenheck JP, Keller BC, Fehringer G, et al. Why Cell-Free DNA Can Be a “Game Changer” for Lung Allograft Monitoring for Rejection and Infection. Curr Pulmonol Rep. 2022.
  5. Levine DJ, Demko ZP, and Ross DJ. Variability in plasma donor-derived cell-free DNA levels with CLAD more than 5-years after Lung Transplantation: Pilot data. Transplantation Reports. 2022;7(3).

Prospera Heart

  1. Kim PJ, Olympios M, Sideris K, et al. A Two-Threshold Algorithm using Donor-derived Cell-free DNA Fraction and Quantity to Detect Acute Rejection After Heart Transplantation. American Journal of Transplantation. https://doi.org/10.1016/j.ajt.2025.04.021.
  2. Deshpande SR, Zangwill SD, Richmond ME, et al. Evaluating Threshold for donor fraction cell-free DNA using Clinically Available Assay for Rejection in Pediatric and Adult Heart Transplantation. Pediatric Transplantation. 2024; 28:e14708. doi :10.1111/petr.14708.
  3. Halloran PH, Reeve J, Mackova M, et al. Comparing Plasma Donor-derived Cell-free DNA to Gene Expression in Endomyocardial Biopsies in the Trifecta-Heart Study. Transplantation. (2024): DOI: 10.1097/TP.0000000000004986.
  4. Kim PJ, Olymbios M, Siu A, et al. A novel donor-derived cell-free DNA assay for the detection of acute rejection in heart transplantation. J Heart Lung Transplant. 2022.