Organ Health Publications

Renasight | Prospera Kidney | Prospera Lung | Prospera Heart

Renasight

1. PKD/Sickle Cell Case Report | Open Access
   Stein Q, Herman K, Deyo J, et al. Dual diagnosis of autosomal dominant polycystic kidney disease and sickle cell disease in a teenage male. Pediatr Nephrol. (2023). 38(9):3189-3192. doi: 10.1007/s00467-023-05873-6
2. Genetic counseling Perspectives | Open Access
   Stein Q, Westemeyer M, Darwish T, et al. Genetic Counseling in Kidney Disease: A Perspective. Kidney Medicine (2023). 5(7):100668. doi: 10.1016/j.xkme.2023.100668.
3. CUBN Case Report | Open Access
   Shi V, Stein Q, Clark D, et al. Isolated benign persistent proteinuria with novel association of CUBN (cubilin) variants. 11(6):e7502. doi: 10.1002/ccr3.7502
4. RenaCARE Primary Readout | Open Access (Published ahead of Print)
   Dahl N, Bloom MS, Chebib FT, et al. The Clinical Utility of Genetic Testing in the Diagnosis and Management of Adults With Chronic Kidney Disease. J Am Soc Nephrol ():10.1681/ASN.0000000000000249.
5. Renasight 1000 | Open Access
   Bleyer AJ, Westemeyer M, Xie J, et al. Genetic Etiologies for Chronic Kidney Disease Revealed through Next-Generation Renal Gene Panel. Am J Nephrol. 2022. 53(4):297-306.
6. Genetic Testing in Kidney Donors | Open Access
   Singh G, Gohh R, Clark D, et al. Vignette-Based Reflections to Inform Genetic Testing Policies in Living Kidney Donors. Genes. 2022;13(4).
7. COL4A4 Case Report | Open Access
   Cocorpus J, Hager MM, Benchimol C, et al. COL4A4 variant recently identified: lessons learned in variant interpretation-a case report. BMC Nephrol. 2022;23(1):253.
8. Alport Case Study | Open Access
   Tantisattamo E, Reddy UG, Ichii H, et al. Is It Time to Utilize Genetic Testing for Living Kidney Donor Evaluation? Nephron 2021. doi: 10.1159/000520150
9. General Nephrology Survey | Open Access
   Mrug M, Bloom MS, Seto C, et al. Genetic Testing for Chronic Kidney Diseases: Clinical Utility and Barriers Perceived by Nephrologists. Kidney Medicine

   (2021) doi: https://doi.org/10.1016/j.xkme.2021.08.006.

10. Renal PGT-M | Open Access
    Chaperon JL, Wemmer NM, McKanna TA, et al. Preimplantation Genetic Testing for Kidney Disease-Related Genes: A Laboratory’s Experience. Am J Nephrol 2021. doi: 10.1159/000518253

Prospera Kidney

1. Elevated Prospera dd-cfdna months prior to bp-rejection | Open Access
   Bromberg, et al. Elevation of Donor-derived Cell-free DNA Before Biopsy-proven Rejection in Kidney Transplant. Transplantation. 2024
2. Trifecta Study: Subthreshold ABMR-like Activity | Open Access
   Halloran, et al. Distinct Molecular Processes Mediate Donor-derived Cell-free DNA Release From Kidney Transplants in Different Disease States. Transplantation. 2023
3. Trifecta Study: Molecular Correlations with cfDNA | Open Access
   Halloran PF, Reeve J, Madill-Thomsen KS, et al. The Trifecta study: comparing plasma donor-derived cell-free DNA levels with the molecular phenotype of kidney transplant biopsies. J Am Soc Nephrol. 2022. 33(2):387-400.
4. Clinical Experience of Prospera in Simultaneous Pancreas-kidney Recipients | Open Access
   Ventura-Aguiar P, Ramirez-Bajo MJ, Rovira J, et al. Donor-derived Cell-free DNA Shows High Sensitivity for the Diagnosis of Pancreas Graft Rejection in Simultaneous Pancreas-kidney. Transplantation. 2022;106(8):1690-1697.
5. Case Study Series of Prospera use in COVID-19 patients | Open Access
   Reusing Jr JO, Yoo J, Desai A, et al. Association between total cell free DNA and SARS-CoV-2 in Kidney Transplant Patients: A Preliminary Study. Transplantation Proceedings. 2022; 54(6):1446-1454.
6. Trifecta Study: Two Threshold Caller Validation | Open Access
   Halloran PF, Reeve J, Madill-Thomsen KS, et al. Combining Donor-derived Cell-free DNA Fraction and Quantity to Detect Kidney Transplant Rejection Using Molecular Diagnoses and Histology as Confirmation. Transplantation. 2022.
7. Trifecta Study: ABMR and DSA | Open Access
   Halloran PF, Reeve J, Madill-Thomsen KS, et al. Antibody-mediated Rejection Without Detectable Donor-specific Antibody Releases Donor-derived Cell-free DNA: Results From the Trifecta Study. Transplantation. 2022.
8. Prospera 1300 Clinical Experience | Open Access
   Qazi Y, Patel A, Fajardo M, et al. Incorporation of Donor-derived Cell-free DNA Into Clinical Practice for Renal Allograft Management. Transplant Proc. 2021. 10:S0041-1345(21)00710-7. doi: 10.1016/j.transproceed.2021.09.027.
9. Single Center Head-to-head Experience of Two dd-cfDNA tests | Open Access
   Lum EL, Nieves-Borrero K, Homkrailas P, et al. Single center experience comparing two clinically available donor derived cell free DNA tests and review of literature. Transplantation Reports. 2021;6(3).
10. Single Center Experience of Improved Sensitivity with Prospera Two Threshold Algorithm over Fraction-alone | Open Access
    Bunnapradist S, Homkrailas P, Ahmed E, et al. Using Both the Fraction and Quantity of Donor-Derived Cell-Free DNA to Detect Kidney Allograft Rejection. J Am Soc Nephrol 2021:32 (10) 2439-2441; DOI: 10.1681/ASN.2021050645
11. Case study of Prospera use in COVID-19 patient | Open Access
    Bunnapradist S, Datta N, Schaenman J, et al. Extremely High Cell-free DNA Levels Observed in Renal Allograft Patient With SARS-CoV-2 Infection. Transplantation Direct. 2021;7(5)
12. CPV-simulated Renal transplants | Open Access
    Peabody J, Billings P, Valdenor C, et al. Randomized clinical trial of a novel donor derived cfDNA test to detect rejection in CPV-simulated renal transplant patients. Int Urol Nephrol. 2020; 52(8):1593-1601.
13. Letter to the Editor Response regarding Prospera Kidney Analytical Validation | Open Access
    Altug Y, Demko ZP, Ryan A. The Author's reply to the "Performance of Donor-derived Cell-free DNA Assays in Kidney Transplant Patients". Letter to the Editors - Transplantation. 2020;104(5):e135-137
14. Survey of Nephrology Practices' Assessment of Renal Allografts | Open Access
    Peabody J, Billings P, Valdenor C, et al. Variation in assessing renal allograft rejection: a national assessment of nephrology practice. International Journal of Nephrology. Vol. 2019; Article ID 5303284, 6 pages.
15. Analytical validation | Open Access
    Altuğ Y, Liang N, Ram R, et al. Analytical Validation of a Single-Nucleotide Polymorphism-Based Donor-Derived Cell-Free DNA Assay for Detecting Rejection in Kidney Transplant Patients. Transplantation. 2019;103(12):2657-2665.
16. Clinical validation | Open Access
    Sigdel TK, Acosta Archila F, Constantin T, et al. Optimizing Detection of Kidney Transplant Injury by Assessment of Donor-Derived Cell-Free DNA via Massively Multiplex PCR. J Clin Med. 2019;8(1):19.

Prospera Lung

1. Single Lung -Slam 
   Arunachalam, Ambalavanan et al. Donor-derived Cell-free DNA is a Valuable Monitoring Tool after Single Lung Transplantation: Multi-center Analysis JHLT Open, Volume 0, Issue 0, 100155
2. ALAD-Spectrum | Open Access
   Girgis R, Lawson C, Bhorade S, et al. Real-World Clinical Experience Implementing Donor-Derived-Cell Free DNA for Detection of Acute Lung Allograft Dysfunction after Lung Transplantation. Mar Pulmonology and Respiratory Medicine (2023) 6:3. DOI:10.1027/margy.2023.0156.
3. Lung Validation | Open Access
   Rosenheck JP, Ross DJ, Botros, M, et al. Clinical Validation of a Plasma Donor-derived Cell-free DNA Assay to Detect Allograft Rejection and Injury in Lung Transplant. Transplantation Direct. 2022;8(4).
4. Game Changer Review | Open Access
   Rosenheck JP, Keller BC, Fehringer G, et al. Why Cell-Free DNA Can Be a “Game Changer” for Lung Allograft Monitoring for Rejection and Infection. Curr Pulmonol Rep. 2022.
5. dd-cfDNA in CLAD | Open Access
   Levine DJ, Demko ZP, and Ross DJ. Variability in plasma donor-derived cell-free DNA levels with CLAD more than 5-years after Lung Transplantation: Pilot data. Transplantation Reports. 2022;7(3).

Prospera Heart

1. DTRT: Pediatric/Adult Heart Validation
   Deshpande SR, Zangwill SD, Richmond ME et al. Evaluating Threshold for donor fraction cell-free DNA using Clinically Available Assay for Rejection in Pediatric and Adult Heart Transplantation. Pediatric Transplantation. 2024; 28:e14708. doi :10.1111/petr.14708.
2. Trifecta Heart | Open Access
   Halloran PH, Reeve J, Mackova M, et al. Comparing Plasma Donor-derived Cell-free DNA to Gene Expression in Endomyocardial Biopsies in the Trifecta-Heart Study. Transplantation. (2024): DOI: 10.1097/TP.0000000000004986.
3. Heart Validation | Open Access
   Kim PJ, Olymbios M, Siu A, et al. A novel donor-derived cell-free DNA assay for the detection of acute rejection in heart transplantation. J Heart Lung Transplant. 2022.