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Now Available: Panorama™ Vanishing Twin Workflow

More accurate calls for more pregnancies

Panorama™ delivers aneuploidy results for the viable twin even in the presence of cell-free DNA (cfDNA) from a vanished twin

VANISH: The first prospective NIPT study to distinguish between twins in a vanishing twin pregnancy1
VANISH
study
results
(n=57)
100%
Accurate viable twin identification
0
False Positives
0
False Negatives
100%
Fetal sex accuracy*
*When fetal sex reported. In clinical practice false positives and false negatives are possible and may occur.

Panorama™ delivers aneuploidy results for the viable twin even in the presence of cell-free DNA (cfDNA) from a vanished twin

VANISH: The first prospective NIPT study to distinguish between twins in a vanishing twin pregnancy1
VANISH study results
(n=57)
100%
Accurate viable twin identification
0
False Positives
0
False Negatives
100%
Fetal sex accuracy*
*When fetal sex reported. In clinical practice false positives and false negatives are possible and may occur.

New vanishing twin workflow

Made possible by the unique SNP-based capabilities of Panorama™

Vanishing Twin Workflow
Top Image Bottom Image

Only Panorama™ can distinguish the viable twin from the vanished twin

Infographic Background
Vanished twin DNA
Viable twin DNA
Number of DNA molecules
SNPs make up the 1% of DNA that make us different
Vanished
twin DNA
Viable
twin DNA
SNP-based Panorama™
Counting NIPTs cannot distinguish twin from twin
Viable and vanished twin DNA
Counting NIPT
Up to 33%
of Trisomy 21 false positives can be attributed to a vanishing twin13
Up to 10%
of vanishing twin pregnancies may receive an incorrect fetal sex result14
Top image: SNP-based Panorama™ illustrates the difference in DNA between viable and vanished twins. Bottom image: Standard NIPT method showing indistinguishable DNA signals from both twins.

Other NIPTs can report inaccurate results and fetal sex errors

Vanishing twins occur in approximately 1% of all pregnancies and 30% of known twin pregnancies8

Icon 1

Vanishing twin pregnancies can result in false positives, false negatives, and fetal sex errors9,15-22

Icon 2

Measurable cfDNA from the vanished twin has been observed up to 16 weeks after fetal demise15,16,23

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References

1 Data on file

2 Benn et al. Prenat Diagn. 2024 Sept; 44(10):1218–1224.

3 Pergament et al. Obstet Gynecol. 2014 Aug; 124(2 Pt 1):210–8.

4 Nicolaides et al. Prenat Diagn. 2013 June; 33(6):575–9.

5 Ryan et al. Fetal Diagn Ther. 2016; 40(3):219–223.

6 Norwitz et al. J Clin Med. 2019 Jun; 8:937.

7 Dar et al. Am J Obstet Gynecol. Jan; 227(1):124–125.

8 Hedriana et al. Prenat Diagn. 2020 Jan; 40(2):179–84.

9 Curnow et al. Am J Obstet Gynecol. 2015 Jan; 212(1):79.e1–9.

10 Kantor et al. Prenat Diagn. 2022 Jul; 42(8):994–999.

11 Nicolaides et al. Fetal Diagn Ther. 2014; 35(3):212–7.

12 Martin et al. Am J Obstet Gynecol MFM. 2020; 2:100152.

13 Porreco RP et al. Am J Obstet Gynecol. 2014; 211:365.e1–12.

14 Balaguer N et al. Prenatal Diagnosis. 2021; 41:1241–1248.

15 Niles KM et al. Ultrasound Obstet Gynecol. 2018 Oct; 52(4):547–548.

16 Chen M et al. Prenat Diagn. 2021 Nov; 41(12):1602–1610.

17 Masala M et al. Prenat Diagn. 2015; 35(5):506–508.

18 Su B et al. Contemp Ob/GYN. April 2015.

19 Niles et al. Ultrasound Obstet Gynecol. 2018; 52(4):547–548.

20 Soto ÁL et al. Taiwan J Obstet Gynecol. 2020; 59(5):652–655.

21 van Eekhout JCA et al. Prenat Diagn. 2023 Jun; 43(7):829–837.

22 Hartwig TS et al. Eur J Obstet Gynecol Reprod Biol. 2018 Jul; 226:35–39.

23 Kleinfinger P et al. Genes (Basel). 2022 Nov; 13(11):2027.

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