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Now Available: Panorama™ Vanishing Twin Workflow

More accurate calls for more pregnancies

Panorama™ delivers aneuploidy results for the viable twin even in the presence of cell-free DNA (cfDNA) from a vanished twin

VANISH: The first prospective NIPT study to distinguish between twins in a vanishing twin pregnancy1
VANISH
study
results
(n=57)
100%
Accurate viable twin identification
0
False Positives
0
False Negatives
100%
Fetal sex accuracy*
*When fetal sex reported. In clinical practice false positives and false negatives are possible and may occur.

WEBINAR

NIPT Evolved:

New insights, real cases, and better decisions

Tuesday, October 7th

9 AM PT / 12 PM ET

2:30 PM PT / 5:30 PM ET

30 minute webinars with 15 min Q&A

Upcoming Webinar

NIPT Evolved: New insights, real cases, and better decisions

Join our webinar with Dr. Christopher Sullivan, Dr. Shailen Shah, and Katie Hashimoto, MS, CGC, to learn how innovations in NIPT can aid clinical decision making and uncover conditions that may otherwise remain undetected.

What you’ll learn:

  • Review the latest advancements and unique capabilities of SNP-based NIPT, including vanishing twins, triploidy, and maternal malignancy
  • Explore real-world case studies where these findings influenced clinical management
  • Ask questions during a live Q&A
Register Now

Panorama™ delivers aneuploidy results for the viable twin even in the presence of cell-free DNA (cfDNA) from a vanished twin

VANISH: The first prospective NIPT study to distinguish between twins in a vanishing twin pregnancy1
VANISH study results
(n=57)
100%
Accurate viable twin identification
0
False Positives
0
False Negatives
100%
Fetal sex accuracy*
*When fetal sex reported. In clinical practice false positives and false negatives are possible and may occur.

New vanishing twin workflow

Made possible by the unique SNP-based capabilities of Panorama™

Vanishing Twin Workflow
Top Image Bottom Image

Only Panorama™ can distinguish the viable twin from the vanished twin

Infographic Background
Vanished twin DNA
Viable twin DNA
Number of DNA molecules
SNPs make up the 1% of DNA that make us different
Vanished
twin DNA
Viable
twin DNA
SNP-based Panorama™
Counting NIPTs cannot distinguish twin from twin
Viable and vanished twin DNA
Counting NIPT
Up to 33%
of Trisomy 21 false positives can be attributed to a vanishing twin13
Up to 10%
of vanishing twin pregnancies may receive an incorrect fetal sex result14
Top image: SNP-based Panorama™ illustrates the difference in DNA between viable and vanished twins. Bottom image: Standard NIPT method showing indistinguishable DNA signals from both twins.

Other NIPTs can report inaccurate results and fetal sex errors

Vanishing twins occur in approximately 1% of all pregnancies and 30% of known twin pregnancies8

Icon 1

Vanishing twin pregnancies can result in false positives, false negatives, and fetal sex errors9,15-22

Icon 2

Measurable cfDNA from the vanished twin has been observed up to 16 weeks after fetal demise15,16,23

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References

1 Data on file

2 Benn et al. Prenat Diagn. 2024 Sept; 44(10):1218–1224.

3 Pergament et al. Obstet Gynecol. 2014 Aug; 124(2 Pt 1):210–8.

4 Nicolaides et al. Prenat Diagn. 2013 June; 33(6):575–9.

5 Ryan et al. Fetal Diagn Ther. 2016; 40(3):219–223.

6 Norwitz et al. J Clin Med. 2019 Jun; 8:937.

7 Dar et al. Am J Obstet Gynecol. Jan; 227(1):124–125.

8 Hedriana et al. Prenat Diagn. 2020 Jan; 40(2):179–84.

9 Curnow et al. Am J Obstet Gynecol. 2015 Jan; 212(1):79.e1–9.

10 Kantor et al. Prenat Diagn. 2022 Jul; 42(8):994–999.

11 Nicolaides et al. Fetal Diagn Ther. 2014; 35(3):212–7.

12 Martin et al. Am J Obstet Gynecol MFM. 2020; 2:100152.

13 Porreco RP et al. Am J Obstet Gynecol. 2014; 211:365.e1–12.

14 Balaguer N et al. Prenatal Diagnosis. 2021; 41:1241–1248.

15 Niles KM et al. Ultrasound Obstet Gynecol. 2018 Oct; 52(4):547–548.

16 Chen M et al. Prenat Diagn. 2021 Nov; 41(12):1602–1610.

17 Masala M et al. Prenat Diagn. 2015; 35(5):506–508.

18 Su B et al. Contemp Ob/GYN. April 2015.

19 Niles et al. Ultrasound Obstet Gynecol. 2018; 52(4):547–548.

20 Soto ÁL et al. Taiwan J Obstet Gynecol. 2020; 59(5):652–655.

21 van Eekhout JCA et al. Prenat Diagn. 2023 Jun; 43(7):829–837.

22 Hartwig TS et al. Eur J Obstet Gynecol Reprod Biol. 2018 Jul; 226:35–39.

23 Kleinfinger P et al. Genes (Basel). 2022 Nov; 13(11):2027.

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