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Optimal trial populations. Earlier Insights. Faster Results.

Natera’s Biopharma Services can help accelerate clinical development with access to unique biomarker-defined populations, earlier molecular insights and integrated MRD, multi-omics and real world data.

MRD-guided enrichment can identify optimal trial populations, yielding clearer efficacy signals and de-risked development pathways.

Natera’s Biopharma Services enable differentiated biomarker-guided trials to help bring life changing therapies to more patients, faster

Access the broadest populations

that may benefit from additional treatment

Expand therapeutic opportunities

in earlier disease settings

Support data-informed trial design

through integrated biomarker, real-world data, and AI-enabled insights

Accelerate clinical development

through earlier efficacy insights and streamlined trial execution

Our Advantage: Expand therapeutic opportunity to broader populations, sooner

Access broader patient populations

Expand your intent to treat populations or target populations with comprehensive biomarker stratification options

Enabled by: Molecular disease quantification, comprehensive genomic profiling, multi-omic assays, AI-enabled response signatures, and diverse RWD

Expand to earlier disease settings

Move drug development from metastatic to perioperative and adjuvant settings by identifying and enriching for higher-risk patients

Enabled by: Molecular disease quantitation to identify likely relapsers

Design more precise, data-informed trial designs

Predict response signatures, optimize trial design, refine inclusion/exclusion criteria, and simulate trial feasibility

Enabled by: Longitudinal RWD and AI-powered simulations and predictions

Execute trials faster

Predict therapy response as early as weeks into therapy initiation, accelerate recruitment, and scale seamlessly across geographies

Enabled by: Molecular disease monitoring, patient recruitment support, and global clinical trial and infrastructure

Solutions Across the Drug Development Lifecycle

Delivering earlier insights for faster execution via a seamless partnership across the development lifecycle

Pre-clinical/Discovery

Which biomarkers and patient populations hold the greatest promise?

  • Size and characterize addressable populations
  • Discover AI-enabled, differentiated biomarkers
  • Benchmark outcomes against standard of care

Early Clinical Development

How quickly can I see if my therapy is working, and in whom?

  • Assess early efficacy within weeks using ctDNA dynamics
  • Identify responder profiles and resistance mechanisms
  • Define the optimal intent-to-treat population

Registrational Trial

How can I optimize trial design and accelerate execution?

  • Optimize trial design and execution with AI-enabled simulations, ctDNA surrogate endpoints, and RWD comparator arms
  • Accelerate recruitment by targeting biomarker-defined patient populations
  • Scale globally through CDx commercialization and regulatory expertise

Multiple Prospective Interventional Studies

Ongoing interventional and prospective studies demonstrate the feasibility and adoption of ctDNA-directed trials across tumor types.
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Combining Deep Scientific Expertise with Broad Commercial Reach

Natera integrates technology, evidence, and infrastructure to enable commercialization and trial execution at scale

Extensive Commercial Footprint1

50%+ of US oncologists reached

300,000+ patients tested to date

40,000+ patients tested monthly

Deep Clinical Validation1

125+ Peer-reviewed publications across

30,000+ patients

30+ tumor types

Proven Biopharma Partnerships1

150+ prospective and retrospective studies

50+ Pharma partners

Global Reach & Access1

30+ Countries with clinical or commercial presence

4,500+ employees worldwide

US, Europe, Japan, China, and APAC operational infrastructure

Partnering for the Future of Oncology Drug Development

Natera enables differentiated, data-informed biomarker-guided trials to help bring therapies to more patients faster. Reach out to learn more.

How can Signatera™ support your clinical trials?

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References

1Natera publicly reported and internal data as of September 2025.

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