Natera Presents Data at ESMO GI on its Tissue-Free Latitude™ MRD* Assay, Demonstrating Excellent Overall Performance in Colorectal Cancer

AUSTIN, Texas–(BUSINESS WIRE)– Natera, Inc. (NASDAQ: NTRA), a global leader in cell-free DNA and precision medicine, today
announced data from a colorectal cancer (CRC) study of its tissue-free Latitude™ MRD assay, which were presented at
the 2025 European Society for Medical Oncology GI Congress (ESMO GI).

The clinical performance of the assay was analyzed in a cohort of ~200 patients (>1,300 plasma samples) with
resectable stage I-IV colorectal cancer. Samples were derived from the GALAXY arm of the CIRCULATE-Japan study, one
of the largest and most comprehensive prospective studies of MRD testing in resectable CRC. Key results include:

• Excellent clinical sensitivity to recurrence: The Latitude assay detected recurrence with 58% sensitivity
  in the post-surgical MRD window and 81% sensitivity in the surveillance setting, with median diagnostic lead time
  of 4.6 months.
• High clinical specificity: In the surveillance setting, patient-level specificity was 92%, and
  sample-level specificity was 97%.
• Highly prognostic of recurrence risk: MRD positivity was significantly associated with inferior outcomes
  during both the MRD (HR: 10, p<0.001) and surveillance (HR: 18, p<0.001) windows.
• Highly predictive of adjuvant chemotherapy (ACT) benefit: Among high-risk stage II and stage III
  patients, those who were MRD-positive after surgery derived significant benefit from ACT (p<0.001), while no
  significant treatment benefit was observed in MRD-negative patients (p=0.54).

“This study demonstrates strong clinical potential for Natera’s tissue-free MRD assay,” said Yoshiaki Nakamura,
M.D., Ph.D., principal investigator of the study. “We clearly observed the prognostic and predictive value of the
assay, seeing strong correlation of recurrence risk and adjuvant treatment outcomes.”

“These results reinforce the data previously presented at ASCO GI, where our tissue-free Latitude MRD assay
demonstrated high overall concordance to Signatera™ as well as strong standalone clinical performance,” said Alexey
Aleshin, M.D., corporate chief medical officer and general manager of oncology at Natera. “When offered alongside
Signatera, our tissue-free assay gives patients and providers the latitude to get a reliable MRD assessment even
when tissue is unavailable.”

Notes
^*MRD = Molecular residual disease

About Natera

Natera™ is a global leader in cell-free DNA and genetic testing, dedicated to oncology, women’s health, and organ
health. We aim to make personalized genetic testing and diagnostics part of the standard-of-care to protect health
and inform earlier, more targeted interventions that help lead to longer, healthier lives. Natera’s tests are
supported by more than 300 peer-reviewed publications that demonstrate excellent performance. Natera operates ISO
13485-certified and CAP-accredited laboratories certified under the Clinical Laboratory Improvement Amendments
(CLIA) in Austin, Texas, and San Carlos, California. For more information, visit www.natera.com.

Forward-Looking Statements

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statements and are not a representation that Natera’s plans, estimates, or expectations will be achieved. These
forward-looking statements represent Natera’s expectations as of the date of this press release, and Natera
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known and unknown risks and uncertainties that may cause actual results to differ materially, including with respect
to whether the results of clinical or other studies will support the use of our product offerings, the impact of
results of such studies, our expectations of the reliability, accuracy and performance of our tests, or of the
benefits of our tests and product offerings to patients, providers and payers. Additional risks and uncertainties
are discussed in greater detail in “Risk Factors” in Natera’s recent filings on Forms 10-K and 10-Q and in other
filings Natera makes with the SEC from time to time. These documents are available at www.natera.com/investors and www.sec.gov.

Source: Natera, Inc.