May Double Rate of Successful Implantation
Preimplantation Genetic Screening and Diagnosis (PGS/PGD) are types of genetic tests to determine if an embryo carries extra or missing chromosomes and/or inherited diseases, such as Cystic Fibrosis. PGS/PGD tests greatly reduce the chance of miscarriage and of having a child with an aneuploidy or a genetic disease of concern.
Preimplantation Genetic Screening (PGS)
- 24-Chromosome Screening: PGS screens for the number of chromosomes in one or a few cells from each embryo of an IVF cycle. Embryos with the normal number of chromosomes (46) have a better chance of implanting and creating a healthy pregnancy. After PGS screening, these embryos can be selected for transfer to the mother's uterus.
Preimplantation Genetic Diagnosis (PGD)
- Single Gene Testing: Available for couples identified to be at risk for having a child with a specific genetic disorder, PGD can test embryos for a specific, single gene mutation, so unaffected embryos can then be chosen for transfer. Spectrum's Single Gene PGD testing is done concurrently with 24-Chromosome PGS on a single embryo sample. Most genetic disorders can be tested if the gene mutations have already been identified in the patient and/or partner.
- Translocation and Inversion Testing: A person who carries a balanced chromosomal rearrangement may have an increased risk of passing on too little or too much genetic information to the embryo, possibly causing infertility, miscarriage, or birth defects and disabilities. Embryos can be tested for extra or missing chromosome pieces, and those with normal or balanced chromosome results are selected for transfer to the uterus.
Clinically Effective PGS/PGD
Spectrum PGS/PGD can increase the chance of success by identifying embryo(s) most likely to result in a healthy pregnancy. Spectrum can determine chromosome copy number, and detect unbalanced rearrangements and/or inherited diseases in an embryo.
Spectrum's key features, include:
- 24-chromosome aneuploidy screening
- Explicitly computes and reports individual chromosome confidence calls, typically >99% accurate
- Determines parental origin of aneuploidy
- Detects DNA contamination
- Corrects for the most common source of PGD misdiagnosis (allele dropout of ADO)
- Single gene PGD testing includes simultaneous 24-chromosome screening
- Screens for abnormal results due to haploidy, triploidy and UPD
(while identifying contamination and confirming parentage)
Who Can Benefit from Spectrum?
IVF patients can improve their chances for a healthy pregnancy when utilizing PGS/PGD, especially for the following indications:
- Advanced maternal age
- Single embryo transfer
- Recurrent pregnancy loss
- Prior child/pregnancy with a chromosomal abnormality
It can also be used to help:
- Maximize a donor cycle
- Determine status of frozen embryos
- Decrease the chance of a chromosomal abnormality in an ongoing pregnancy
Ask your doctor if Spectrum is right for you.