Natera’s Preimplantation Genetic Screening (PGS) and Preimplantation Genetic Diagnosis (PGD)

Delivering on the Promise

PGS and PGD are types of genetic tests used during in vitro fertilization (IVF) to test an embryo for extra or missing chromosomes and/or inherited diseases, like Cystic Fibrosis. The goal of both PGS and PGD testing is to find out which embryos are most likely to result in a healthy pregnancy.

Both PGS and PGD are done on an embryo biopsy as part of an IVF cycle. PGS screens embryos for whole extra or missing chromosomes. PGD tests embryos for a specific genetic disease or small extra or missing pieces of chromosomes.

PGS or PGD tests are done after fertilization by removing a single cell or multiple cells from a developing embryo for testing. The biopsy is performed by an embryologist at an IVF center. It can be done either 3 days or 5 days after fertilization. In either case, the biopsy samples are sent to Natera for testing. The embryos remain at the IVF center. Once results are given to your IVF doctor, you and your doctor decide which embryos to transfer.

Which PGS/PGD test is right for you?

Embryos with whole extra or missing chromosomes usually do not develop correctly. These embryos may:

  • not implant after transfer
  • miscarry during a pregnancy
  • result in a baby born with disabilities or birth defects

Natera’s 24-Chromosome PGS with Parental Support™ can tell you which embryo samples have the correct number of chromosomes and which have an abnormal number of chromosomes.

24-Chromosome PGS may be helpful to anyone wanting to improve their chances of having a successful IVF cycle. Studies have shown that this testing may be particularly helpful for couples with a:

  • Female partner age 35 or older
  • History of more than one miscarriage
  • Previous unsuccessful IVF cycle
  • Prior pregnancy with a chromosome abnormality

For more information about Natera’s 24-Chromosome PGS with Parental Support™, choose:

If you or your partner carries a balanced chromosome rearrangement, such as a translocation or an inversion, you may have an increased risk of passing on too little or too much genetic information to your embryos. This can cause infertility, miscarriage, or birth defects and disabilities. Natera’s Translocation PGD looks for these extra or missing chromosome pieces. At the same time, it looks for whole extra or missing copies of all the chromosomes.

For more information about Natera’s PGD Translocation testing with Parental Support™, choose:

Single gene PGD testing is available for couples who know they are at risk for having a child with a specific genetic disorder. Embryos are tested for the specific gene mutations that you and/or your partner carry. Unaffected embryos are then chosen for transfer. Natera’s Single Gene PGD testing can be done at the same time as 24-Chromosome PGS on a single embryo sample.

Single gene PGD can be done for most genetic disorders but only if the gene mutations have already been identified in you and/or your partner.

For more information regarding Natera’s Single Gene PGD testing with Parental Support™, choose:

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