Panorama For Twins

Panorama
for twins

Panorama
for twins

Panorama
for twins

Panorama
for twins

Panorama now offers screening for twin, egg donor, and surrogate pregnancies!

Conditions screened in twin, egg donor, and surrogate pregnancies:

  • Trisomy 21
  • Trisomy 18
  • Trisomy 13
  • Sex chromosome trisomies (reported when seen)*
  • 22q11.2 deletion syndrome (optional)*

* Available only for monozygotic twins only

For twin pregnancies, only Panorama can provide:

  • Zygosity information
  • Individual fetal fractions for dizygotic twins
  • Fetal sex for each twin
  • Monosomy X risk for monozygotic twins

Panorama screened for trisomies 21, 18, and 13 in twin pregnancies with a combined sensitivity of >99% and specificity of >99% in a validation study.1

Panorama helps clinicians identify higher risk for conditions that affect more than

1 in 45

twin pregnancies2-12

Monozygotic-monochorionic pregnancies are at risk of developing twin-twin transfusion syndrome and other complications2-7

 

Twin-twin transfusion syndrome (TTTS) is a severe condition that affects about 10% of monochorionic-diamniotic pregnancies.2 The fetuses’ blood vessels in the shared placenta are connected, which can result in an unequal sharing of blood.

Monochorionic-diamniotic pregnancies should be monitored closely for signs of TTTS. Early identification of twin pregnancies at risk for TTTS allows for appropriate surveillance, diagnosis, and intervention, which can improve outcomes for both twins.

Monochorionic-monoamniotic twin pregnancies are less common, but are at higher risk for serious complications, such as cord entanglement and cord compression – among others.

Diagnosing both amnionicity and chorionicity correctly is an important step in the management of twin pregnancies.

Panorama may help clinicians triage twin pregnancies effectively2-7

Panorama identified monozygotic twins with >99% sensitivity and specificity in a validation study.1

While chorionicity can be reliably detected early in pregnancy, studies have shown that up to 19% of monochorionic pregnancies are incorrectly classified as dichorionic.4 Panorama allows clinicians to align their ultrasound findings with an early and accurate zygosity determination.

  • Identifying a monozygotic twin pregnancy with Panorama can prompt earlier, targeted ultrasound assessments for chorionicity and associated complications. 
  • Knowing that a twin pregnancy is dizygotic reduces healthcare providers’ and patients’ concerns about TTTS.

Pregnancy management of twins is highly influenced by chorionicity; as such, Panorama’s zygosity determination can help healthcare providers determine an appropriate management plan. 

 

 

 

 

Only Panorama reports individual fetal fractions for dizygotic twins

Accurate fetal fraction measurement and reporting is essential for accurate NIPT results.13

Panorama’s strict fetal fraction standards reduces the risk that insufficient fetal DNA from either twin will result in a false negative result. Our quality control means reliable results for your patients.

 

References

  1. Natera validation data.  Manuscript in preparation
  2. Society for Maternal-Fetal Medicine, Clinical guideline: Twin-twin transfusion syndrome, Jan 2013.
  3. American College of Obstetricians and Gynecologists and Society for Maternal-Fetal Medicine, Practice Bulletin No. 169, Oct 2016.
  4. Blumenfeld et al. J Ultrasound in Med. 2014 Dec;33(12):2187-92.
  5. Oldenburg et al. Ultrasound Obstet Gynecol 2012; 39: 69–74.
  6. Chasen, Chervenak. Twin pregnancy: Prenatal issues. In: UpToDate, Post, CL, DL (Ed), UpToDate, Aug 2017.
  7. Cunningham et al. Williams Obstetrics. 24th edition. New York: McGraw-Hill Education, 2014.
  8. Boyle et al. British Journal of Obstetrics and Gynaecology. 2014 Feb; 121(7):809-20
  9. Sparks et al. Obstet Gynecol. 2016 Nov;128(5):1127-33
  10. Rodis et al. Obstet Gynecol. 1990 Dec;76(6):1037-41
  11. http://ghr.nlm.nih.gov/condition/trisomy-18
  12. http://ghr.nlm.nih.gov/condition/trisomy-13
  13. Wright et al. Ultrasound Obstet Gynecol. 2015;45:48-54.

 

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