Highly accurate NIPT

See our latest paper

Highly accurate NIPT

See our latest paper

Highly accurate NIPT

See our latest paper

Highly accurate NIPT

See our latest paper

About Panorama

Panorama^® is a noninvasive prenatal test (NIPT) that analyzes fetal-placental, cell-free DNA isolated from maternal plasma as early as nine weeks into gestation. Panorama offers highly accurate, comprehensive panels to screen for fetal aneuploidies and microdeletion syndromes. Panorama has been evaluated in 12 peer-reviewed publications and in more than 60,000 pregnancies.

The Panorama Advantage

Offer your patients NIPT

Non-invasive prenatal testing (NIPT) can prompt a diagnostic journey that gives families time to prepare for the birth of a child with a genetic disorder. ACMG recommends that women of all ages be informed that NIPT is the most sensitive screening test for traditionally screened aneuploidies, including Down syndrome. While the prevalence of some conditions, such as Down syndrome, increases with maternal age, microdeletions occur randomly, meaning women of all ages are at equal risk. Panorama NIPT is highly accurate when compared to maternal serum screening and it poses no risk of miscarriage, unlike diagnostic procedures such as amniocentesis.

A proven leader in the market

Panorama combines high accuracy with a low rate of test failure.

Panorama incorporates maternal age and fetal fraction into the calculation of every risk score and includes fetal fraction on every report.
Panorama only reports results on samples that meet Natera’s quality metrics. The observed redraw rate in clinical experience is 4%.
Panorama’s SNP-based methodology enables high confidence calls at lower fetal fractions (2.8% or above).

NIPT: any woman, any age

Since 2012, more than 68,613 patients younger than 35 years of age have been evaluated in eight studies.
28 health plans covering more than 75.1 million lives have updated their medical policies to include NIPTs as medically necessary for fetal aneuploidies in all singleton pregnancies.
Panorama is validated in both high- and average-risk cohorts and demonstrates similar positive predictive values (PPV).

Screening for all maternal ages

Panorama: the power of SNPs

Panorama is the only commercially available NIPT that specifically analyzes single nucleotide polymorphisms (SNPs) to determine chromosome copy number. Validated at fetal fraction as low as 2.8%, this approach sequences cell-free DNA from maternal plasma to infer the fetal genotype. Panorama targets 13,392 SNPs covering chromosomes 21, 18, 13, X, and Y; additional sets of SNPs are targeted for identification of microdeletions. A patented algorithm is then used to determine the chance for fetal chromosome abnormalities and fetal sex (when requested).

The ability to differentiate between maternal and fetal placental DNA also enables Panorama to identify the presence of a vanishing twin and to minimize false positives due to maternal abnormalities. Panorama is uniquely able to identify triploidy and complete molar pregnancies.

Sensitivity and false positive rates

Panorama Average Risk Table

Pergament et al. Obstet Gynecol 2014; 124 (2 Pt 1):210-8. doi: 10.1097/AOG.0000000000000363.
Nicolaides, et al. Prenatal Diagnosis 2013; DOI: 10.1002/pd.4103.
Ryan, et al. Fetal Diagn Ther 2016; DOI: 10.1159/000442931.
Wapner et al. Am J Obstet Gynecol 2015; 212(3): 332.e1-9.
Norton et al. N Engl J Med 2015; 372:1589-1597.

The importance of fetal fraction

Natera’s groundbreaking study of over 1,000 pregnancies with low fetal fraction showed the importance of incorporating fetal fraction into NIPT risk assessment. Learn more here.

Joint Statement of the American Congress of Obstetrics and Gynecology and the Society for Maternal-Fetal Medicine:

“Fetal fraction…is essential for accurate results.”

According to the joint statement, failure to measure fetal fraction can increase the chance of a false-negative result.

"The ability to differentiate maternal and fetal DNA is reduced at lower fetal fractions."
"Detection of subchromosomal microdeletions improves significantly at higher fetal fractions."

International Society for Prenatal Diagnosis:

“Failure to measure fetal fraction may be falsely reassuring if the cfDNA screening test is not sufficiently sensitive to recognize abnormality in a sample with a very low fetal fraction.”

National Society of Genetic Counselors:

“Unlike diagnostic testing, cfDNA results can be confounded by low fetal fraction…”

The importance of fetal fraction

Natera’s groundbreaking study of over 1,000 pregnancies with low fetal fraction showed the importance of incorporating fetal fraction into NIPT risk assessment. Learn more here.

Joint Statement of the American Congress of Obstetrics and Gynecology and the Society for Maternal-Fetal Medicine:

“Fetal fraction…is essential for accurate results.”

According to the joint statement, failure to measure fetal fraction can increase the chance of a false-negative result.

"The ability to differentiate maternal and fetal DNA is reduced at lower fetal fractions."
"Detection of subchromosomal microdeletions improves significantly at higher fetal fractions."

International Society for Prenatal Diagnosis:

“Failure to measure fetal fraction may be falsely reassuring if the cfDNA screening test is not sufficiently sensitive to recognize abnormality in a sample with a very low fetal fraction.”

National Society of Genetic Counselors:

“Unlike diagnostic testing, cfDNA results can be confounded by low fetal fraction…”

The importance of fetal fraction

Natera’s groundbreaking study of over 1,000 pregnancies with low fetal fraction showed the importance of incorporating fetal fraction into NIPT risk assessment. Learn more here.

Joint Statement of the American Congress of Obstetrics and Gynecology and the Society for Maternal-Fetal Medicine:

“Fetal fraction…is essential for accurate results.”

According to the joint statement, failure to measure fetal fraction can increase the chance of a false-negative result.

"The ability to differentiate maternal and fetal DNA is reduced at lower fetal fractions."
"Detection of subchromosomal microdeletions improves significantly at higher fetal fractions."

International Society for Prenatal Diagnosis:

“Failure to measure fetal fraction may be falsely reassuring if the cfDNA screening test is not sufficiently sensitive to recognize abnormality in a sample with a very low fetal fraction.”

National Society of Genetic Counselors:

“Unlike diagnostic testing, cfDNA results can be confounded by low fetal fraction…”

The importance of fetal fraction

Natera’s groundbreaking study of over 1,000 pregnancies with low fetal fraction showed the importance of incorporating fetal fraction into NIPT risk assessment. Learn more here.

Joint Statement of the American Congress of Obstetrics and Gynecology and the Society for Maternal-Fetal Medicine:

“Fetal fraction…is essential for accurate results.”

According to the joint statement, failure to measure fetal fraction can increase the chance of a false-negative result.

"The ability to differentiate maternal and fetal DNA is reduced at lower fetal fractions."
"Detection of subchromosomal microdeletions improves significantly at higher fetal fractions."

International Society for Prenatal Diagnosis:

“Failure to measure fetal fraction may be falsely reassuring if the cfDNA screening test is not sufficiently sensitive to recognize abnormality in a sample with a very low fetal fraction.”

National Society of Genetic Counselors:

“Unlike diagnostic testing, cfDNA results can be confounded by low fetal fraction…”

Sample reports

High Risk for Trisomy 21

High Risk for 22q11.2 deletion syndrome

Low risk for all conditions

The Panorama process

Maternal Blood

Maternal/Placental & Fetal cfDNA

SNP Sequencing of Maternal/Placental & Fetal Genotype

Advanced Bioformatics

Test Report

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