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PGD for Detection of Unbalanced Chromosome Rearrangements

Improve your chances for a successful IVF cycle and a healthy pregnancy.

If you or your partner carries a balanced chromosomal rearrangement, also called a translocation, you may have experienced miscarriage, infertility, or the birth of a child with chromosomal abnormalities. Fortunately, it is still possible to have a healthy pregnancy and a healthy baby.

People with balanced translocations often aren’t even aware of the condition, as they typically experience no symptoms. However, people who carry balanced chromosome rearrangements are at a higher risk of creating eggs or sperm with an unbalanced chromosome state, leading to embryos with unbalanced chromosome rearrangements. These chromosomal abnormalities often lead to failed implantation, miscarriage or, in rare cases, the birth of a baby with birth defects or mental retardation.

Improve your chances for a healthy baby with PGD for Detection of Unbalanced Chromosome Rearrangements in addition to 24 Chromosome Aneuploidy Screening with Parental Support (PGS). PGD is a specialized laboratory test used during in vitro fertilization to identify embryos with normal or balanced chromosomes. Natera’s testing method uses a proprietary technology called Parental Support, which examines the translocation, in addition to all the remaining chromosomes, and delivers results that are typically >99% accurate. This test helps your IVF doctor to determine which embryos to transfer to raise your prospects for implantation, pregnancy, and the birth of a healthy child.

Is testing right for you?

PGD for translocations is beneficial if you or your partner carries a balanced chromosome rearrangement.

If you have experienced recurrent miscarriages of unknown cause, or have had a child with an unbalanced chromosome rearrangement, you may want to ask your doctor about chromosome testing, called karyotyping, for both you and your partner. Karyotyping can determine whether you or your partner is a carrier for a translocation or inversions.

Please contact your physician or genetic counselor to discuss testing.

Please note that testing for unbalanced chromosome arrangements in embryos requires approval from the Natera laboratory team in advance. This review and approval process is performed at no cost. See Next Steps below for Natera’s translocation testing to learn how to get started.

 

 

Next steps 

  1. Find a Natera partner IVF clinic.
  2. Ask your physician for Natera testing and have him/her send in a referral and your karyotype report.
  3. Complete your sample collection kit and send to Natera.
  4. Schedule a genetic counseling session.